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Sanford said something else surprising stands out in his research: Most new users didn't switch from cigarettes to smokeless products, meaning those products were their first introduction to nicotine

Oxidative Stress: Toxins found in cigarette smoke can cause oxidative damage to testosterone-producing cells, including Leydig cells within the testes

The Chinese consumed tobacco as early as the 1500s, however cigarettes didnt arrive until the late 1800s, after the invention of the cigarette machine in 1881

H.et al (2008)

For more information on oral health, including prevention, care and treatment of dental disease, visit the ADAs consumer website MouthHealthy.org